Frequently Asked Questions​

Most frequent questions and answers

WHAT IS GENETIC SCREENING?
Genetic screening is a type of test that identifies changes in genes. The results can confirm or rule out a suspected genetic condition or help determine a person’s chance of developing or passing on a genetic disorder including Cancer.
WHAT IS DNA?
A molecule composed of 2 chains coiled around each other to form a double helix carrying genetic instructions for the development, functioning, growth and reproduction of all known organisms.
WHY NEED TO DO DNA SCREENING?
To determine the heredity of mutated genes related to cancer/ disease. To consider early preventive or precaution measures towards cancer/ disease.
WHO SHOULD DO DNA SCREENING?
those with a family history of cancer, diabetes, heart diseases or hereditary diseases those who are on medications
WHAT IS mRNA?
mRNA is a large family of RNA molecules that convey genetic information from DNA to specify the protein products of gene expression.
WHY mRNA SCREENING?
When a CT, MRI, PEP scan views an ‘image’, it means a tumour has already formed! mRNA can screen the mutated gene expression level BEFORE a tumour is formed! Early detection prevents the occurrence of a disease To monitor the changes in gene expression that indicates a disease to relapse, like cancer To determine the types of treatment or medications suitable for a patient
WHO SHOULD DO mRNA SCREENING?
Post-diseased patients to monitor relapse of cancer Those on long term medication
WHAT ARE THE DIFFERENCES BETWEEN BLOOD TESTS-DNA-mRNA SCREENING?
Blood Test: Diagnostic test - Changes due to internal/ external factors DNA: Hereditary test - Static (does not change) mRNA: External (environmental) impact test - Real-time (keeps on changing)
WHAT DOES IT MEAN WHEN CANCER MARKERS IN BLOOD TESTS SHOW POSITIVE?
It means that the expression of the mutated gene related to a certain cancer and can cause its development is present.
Cancer recurs because small number of cancer cells may remain in the body after treatment.
When a CT, MRI, PEP scan views an ‘image’, it means a tumour has already formed! mRNA can screen the mutated gene expression level BEFORE a tumour is formed! Early detection prevents the occurrence of a disease To monitor the changes in gene expression that indicates a disease to relapse, like cancer To determine the types of treatment or medications suitable for a patient
WHAT IS WHOLE EXOME SEQUENCING (WES)?
WES sequences only 1.5% of the whole human genome which is 30 million base pairs
WHY DO GENETIC SCREENING?
DNA screening identifies changes in genes, inherited from our parents, which can be passed on to the next generation.
WHAT IS DNA SCREENING?
DNA screening identifies changes in genes, inherited from our parents, which can be passed on to the next generation.
To be aware of the presence of hereditary mutated genes and to take preventive measures prior to developing cancer/ disease.
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HOW OFTEN SHOULD WE DO DNA SCREENING?
ONCE in a lifetime.
WHAT IS mRNA SCREENING?
mRNA screening can identify real-time changes in gene expression levels before it progresses into a disease or tumour.
HOW DOES mRNA SCREENING HELP?
Knowing the expression level of the genes will enable your Doctor to take preventive, proactive treatment measures.
HOW OFTEN SHOULD WE DO mRNA SCREENING?
Annually depending on the individual and the health conditions of a person
AT WHAT STAGE WILL DNA TEST REVEAL THE DEFECTED GENES IN CANCER?
As early as stage 0 of cancer.
CAN BLOOD TESTS IDENTIFY THE SOURCE OF THE DEFECTIVE GENES TO WHICH ORGAN?
No. Blood test reveals the end-results of a disease.
WHAT CAN BE DONE TO MONITOR THE RELAPSE?
Conducting an annual mRNA screening to monitor the progression of these cells’ mutation will help gauge the necessary measures to be taken.
WHAT IS WHOLE GENOME SEQUENCING (WGS)?
WGS sequences the complete DNA of an organism. In a human there are about 3.3 billion base pairs of a whole genome

WHAT ARE THE DIFFERENCES BETWEEN WGS & WES?

 WGSWES
Sequencing regionCoverageTotal size
Whole genomeintron (non-protein coding region) and exons intron (protein coding region)3.3 billion base pairs
Whole exomeCovers only exons30 million base pairs

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